There are so many variations of spellings of this surname; lists won't ever be complete. Kaighn > Kaighnin > Kaighnen .. just to start
http://www.isle-of-man.com/manxnotebook/fulltext/scrap3/ch03.htm
Kaighan, -in. ?MacAkoen, Abbey Boundaries, 14th cent. ; MacCaghen, 1513, Chaginge, 1635, Kaighin, 1696. Sc. Eachdonn (not Each-tigheayna, as I stated in A Second Manx Scrapbook, page 67). Mod. Sc. McEachan, McGeachan. (McEachern from Eachtig-hearna.) Or perhaps from Ir. MacEachain. In either case the sense is, broadly, a horseman. Caughan (q.v.) is probably cognate. Caken, 1510, Rushen, appears unrelated to Kaighan of German. One of the Bishop's servants in 1354 was named de Cakan.
In the American Colonies
- West Jersey Province = an early emigrant from the Isle of Man who married a member of the Alberson/Preston contingent :
John Kaighn, III the surname continues to this day in the KAIGHN line (2019) A "Kaighn Avenue" remains in modern Camden, New Jersey. AS OF 2019 there are many of his descendants here on Geni.