Using modern scholarship, which has largely disproven a good deal of the earlier genealogies of the Maharal, we now have Chaim of Issenheim as the maternal grandfather of MaHaRaL of Prague - המהר״ל מפראג, rather than the paternal grandfather (who is a different Chaim).
See A. Putik and D. Polakovic (2009) 'Judah Loew ben Bezalel, Called Maharal * A study on his genealogy and biography', in P. Demetz (ed) Path of Life. Rabbi Judah Loew ben Bezalel ca. 1525*1609, Academia, Prague, pp29-83.
Now the task should be to review the sources for the ancestry of Chaim of Issenheim. Can we add some sources to the profiles? It seems a bit like someone just invented a line going back. Is there any truth to it?