Chaim of Issenheim, [Maharal Mat-Gd.father]

Not the paternal grandfather of the Maharal, but possibly the maternal grandfather. Modern scholarship has refuted the idea that this Chaim is the paternal grandfather. See A. Putik and D. Polakovic (2009) 'Judah Loew ben Bezalel, Called Maharal * A study on his genealogy and biography', in P. Demetz (ed) Path of Life. Rabbi Judah Loew ben Bezalel ca. 1525*1609, Academia, Prague, pp29-83. https://tinyurl.com/stjl3oq

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