Update 4 January 2024:
Y‐DNA testing has conclusively proven that Capt, Matthew Fuller, of Barnstable was not a son of Edward Fuller, "Mayflower" Passenger
Extensive Y‐DNA testng was completed as part of the Fuller Big Y DNA Project. Specifics of the DNA testng were reported in the Summer 2022 Issue of The Mayflower Descendant, published by the New England Historical and Genealogical Society. The conclusion of this testing was:
The NGSY‐DNA results demonstrate that Matthew Fuller cannot be Edward’s son or descendant and that the immigrant Robert Fuller is more closely related to Matthew than Matthew is to Edward. In sum, all three men are kinsmen, but no father‐son relationship exists among them. The genealogical timeline makes such kinship impossible.
References:
This affects the descendant lines of 4 of the 5 children of Matthew Fuller and his wife Frances Fuller
But not the children of Anna (Fuller) Fuller who married Samuel Fuller (son of Samuel Fuller, "Mayflower" Passenger & his wife Jane Fuller)
Y DNA is the male line for descendants.
https://www.familytreedna.com/groups/fuller-family-finder/about/bac...
Matthew Fuller (born about 1605, died 1678) arrived some time after Edward (by 1640). Matthew married Frances and had five children -- some researchers believe Matthew was a son of John Fuller, brother to Edward and Samuel of the Mayflower. Others have suggested Matthew was a son of Mayflower passenger Edward. Matthew's parentage is still subject to evaluation, but Big Y DNA results indicate that Matthew was not a biological son of either Edward of the Mayflower nor his brother John.