Hi Adam,
I would like to throw in an observation, hopefully, to further inform the discussion. One of the two profiles for Esther shows her married to an R' Isaac ABD Tykocin (which also appears to be a duplication of a similar profile), while the other shows her married to R' Moses. I want to bring to your attention that this R' Isaac ABD Tykocin has been documented in Unbroken Chain (in a footnote) to have been married to Beila, daughter of R. Mordecai Segal. So... I'm noting here that one of the two profiles you have for Esther indicates that she was born a Segal, just as Beila was born a Segal. If this is correct, it begs the question of how the 2 of them might be related.
Incidentally, Itzjak Halpern, ABD Tykocin is not actually a descendant of the Meir of Padua, so is only mentioned in UC because his son married an unnamed daughter of R' Jacob Shor, and so the descendants of that son are covered in the section of the book on the descendants of Jacob Shor.
Claudia