Edward B. Sizemore - Parents: George All Sizemore and Agnes Shephard

Not sure what your question is but the answer is probably “no one knows for sure.”

It is in the title of the post

Is Edward the son of George “of all” Sizemore & Agnes Shepherd? I have done extensive testing with other Sizemore cousin’s & my closest connections are with the John Sizemore/Rhoda Brock branch of Sizemore’s. I am descended from both Mary Alice Sizemore & Edward Sizemore.

Elizabeth Rachel Sizemore (born Jackson)

MyHeritage Family Trees
Family tree (Stanley and Allied Families) in Family site (BackupMyTree), managed by Paul Stanley
Birth: 1728
Death: 1790
Parents: William "chief Bear" Hart Jackson, Dorcas Jackson (born Green)
Husband: Edward "old Ned" Sizemore
Children: George "chief Of All" Sizemore, Edward 'ned' Sizemore

George Edward Sizemore

MyHeritage Family Trees
shana baker family tree in Shana Web Site, managed by shana schmidt
Birth: 1750 - Lunenberg, Virginia, United States
Death: 1820 - Ashe, North Carolina, United States
Parents: Roda Cornett, William Shepherd
Siblings: Agnes Cornett Shepherd, Agnes Shepherd Cornett, Agnes Cornett Shepherd, Sarah Ann Shepherd, Annis Sheperd, David Sheperd, James Sheperd, Pleasant Sheperd, William Sheperd, Frances Sheperd, Susannah Sheperd, Mary Sheperd

My answer is the same: no one knows for sure.