Acute Intermitted Porphyria

Hello cousin,
I hope you are recovering quickly. I don't know anything about AIP. Would you like me to create a project for AIP??? It is a rare condition & would also go in the Genetic linked umbrella project in the Medical Portal project ([https://www.geni.com/projects/Genetic-Linked-Disorders-Umbrella/51392). I saw that you are following the Porphyria project.

If I create a project for AIP, I can add you to those I invite to collaborate on it. In fact, would you like me to add your name to the list of those I invite to collaborate when I create projects (usually medical, sometimes other topics)??? (I have 12 people on this list at present.)

I created the Medical Portal to organize all of the project that are medically related. I was surprised how many there were and with help added a few more!!! See: https://www.geni.com/projects/Medical-Portal/47725

I have created many of the cause of death projects in the Cause of Death portal: https://www.geni.com/projects/Cause-of-death-portal/27730

2 discussions you may want to follow, if you don't already:

* https://www.geni.com/discussions/172707 Cause of Death Projects needed??? (links to pg 1 as I don't know what pg we are on...)
*** Use this site if you have a cause of death that you don’t find in the Cause of death portal… this is a site I started to kind of keep them all in one place (makes response easier).  I monitor this site freq so would respond quickly if you put a question or need for a new death related project. (Numerous people & curators follow this & often add their comments / observations.)

* https://www.geni.com/discussions/179625?msg=1207663 Medical Portal project--Needs, questions, concerns & related issues Discussion (this links to pg 1)

If you are interested in taking a break from working on your family tree ++, and would like to learn something or have a chuckle here are two discussions you may want to check out:
* https://www.geni.com/discussions/135115?msg=1157650&page=1 Genealogy Humor -- (links to pg 1)
*** This discussion is one I started.  It started as a site for Genealogy humor, but has progressed to humor of all sorts (clean & hopefully not offensive!!!) Sometimes includes informative messages esp. about holidays and occasionally inspirational messages. (Feel free to add jokes, inspiration or informative messages.)

* https://www.geni.com/projects/Picture-Board-for-Genealogy-Humor-Dis... Picture Bd for Geni Humor Discussion
*** This site is a good place to put those genealogy related cartoons or other related pix for the Genealogy humor discussion. Click on “Photos & Documents” to get to “Photos & Documents for Picture Board for Genealogy Humor Discussion”

Hugs & Angels be with you,
Your 23rd cousin, Pat

Hello @Patricia Ann Scoggin Nice to meet you cuz. You can add me to all medical projects. I also have Lupus and Anti-Phospholipid Syndrome which is an auto-immune disease.
My mother also have Porphyria, but not sure what type. I see there is now 9 diffidifferent ones.

Hi Nadia
There are 8 different types of porphyria. I have VP. AIP is less common in South Africa than VP. Like VP it is an inherited condition and is passed on from generation to generation. I have a Facebook PORPHYRIASA page if you would like to join. https://www.facebook.com/groups/porphyriasa/

@https://www.facebook.com/groups/porphyriasa/

Private User Nice to meet you cuz.
Cecilia Strauss is your 7th cousin.

I am aware of all the different porphyria's there is, and that AIP quite rare is in South Africa, I was diagnosed with porphyria when I was 11 years old. And when I had an acute attack in 2010. But my test for VP is negative. I think mine got mixed up because family from my mom's side and my father's side have porphyria.

Recent studies suggest chemicalaly induced porphyria more often part of Acute intermiitent porphyria .

https://pubmed.ncbi.nlm.nih.gov/27622758/

The attack of acute porphyria Based on in silico evidence of pharmacokinetic, pharmacodynamic, and physiologic properties, have approximately 1 300 medicinal drugs been assessed with regard to the specific risk to carriers of acute porphyria. The classifications have been published in booklet form, together with prophylactic advice to the carriers and suggestions for doctors in charge of their care. The risk-classifications rest on the behavior of the drug in an extended molecular model of the attack of acute porphyria. In this, symptoms are effects of 5-aminolevulinate (ALA) produced in surplus after acceleration of enzyme-deficient heme biosynthesis, taking place during induction of drug-metabolizing cytochromes P450 and triggered by hepatocellular nuclear receptors, activated by the drug. The process is enhanced by glucagon- and sirtuin-dependent molecular processes activated in stress and cellular energy deficit, and enhanced and prolonged by auto-generating ALA.