Michelangelo - Michelangelo living descendants

Direct descendants, no - there is no evidence that he had any children by anyone, and some fairly strong evidence that he was all the way over to the "gay" side of the scale.

Collateral descendants, maybe - there is a namesake grand-nephew on record. https://en.wikipedia.org/wiki/Michelangelo_Buonarroti_the_Younger

Collateral family tree looks rather promising.

Michelangelo was never married, even though he did have affairs from time to time. So, we should remove Tommaso dei Cavalieri as a partner of Michelangelo because he was not married to anyone, not even another man.

Maybe the object of the greatest expression of Michelangelo's love, perhaps, but I don't think they were actually "married" or even had a marriage. And also Michelangelo never married because according to many sources, he never married or had a known romantic partner and nor did he have any known children.