It looks like a genealogical confusion.
https://media.geni.com/p13/ff/f0/52/57/5344483aa2edcea4/boonestatio... Identifies the wife of John Bledsoe as a daughter of William White & Elizabeth Boone, but a (now removed) Findagrave memorial noted:
“William White had a sister named Elizabeth Isabella White, possibly confused as a daughter (ca 1749-ca 1814 Winchester, Clark Co., KY, married VA 1774- John Bledsoe ca 1742 VA-1799 Clark Co., KY, Will Book I, p. 195)”
I’m tending to believe the findagrave generationally but we should add more citations. There are sources attached to the profiles.
This discussion however places her as the daughter of William White, her siblings as
https://www.ancestry.com/boards/surnames.boone/2002.2533.2534.2531/...
In addition to
(1) Elizabeth Isabell White, other children of Elizabeth Boone and William White (according to Kelly Kay King) were:
(2) Mary "Polly" White m. James Brooks
(3)Rebecca White m. Isaac Wilcoxson
(4)Levi White m. Elizabeth Wood
(5)William White m. "?"
I looked at the descendant list for Samuel Boone
http://services.dar.org/public/dar_research/search_adb/?action=full...
And indeed there are Bledsoe’s but they are going through Mary (White) Brooks.