Rabbi Isaac Wolf Bunim-Meisels, of Vilna wasn't g.son of REMA. It isn't possible he married his sister.
https://he.wikipedia.org/wiki/%D7%9E%D7%A9%D7%94_%D7%91%D7%9F_%D7%9...
hi netanel(my 10th cousin),
Both the rema and Rabbi Isaac Wolf Bunim-Meisels, of Vilna, are my great grandfather, from two different directions. I did not see that he was the son of the rema or his sister's husband. Did I miss something? Where is this information written in geni? (I only refer to information that appears in master profiles)
Son of Rabbi Simcha Bunim Meisels, [ABD Krakow] and Dreisel Meisels (Isserles)
Husband of Leah Meisels
Father of Rabbi Moshe HaCohen Meisels, [Ba'al "Mahadura Batra"]; Rabbi Binyamin Shimon Zeev Wolf Ashkenazi, [of Vilna]; Simcha Simon-Binyamin Wulf ben Isaac Wolf, of Vilna; NN Loeb; NN Sundel and 4 others
Brother of ***Leah Meisels***; Moshe Eliezer Meisels; Shulem Meisel; Miriam Meisels; Shimon Wulfe Meiseles; and Yehuda Leib Meisels, ABD in Belarus? « less
That from Rabbi Isaac Master Profile page.
He can't be brother of his wife Leah Meisles.
Leah was g.son of the Rema, because that her family was so famous they take her parent's surname, bur Rabbi Isaac surname wasn't Meisles