There are a few issues here, and if any researchers have documents or source citations to share, those would certainly help.
BIRTH: Anthony's birth year is 1735, which is two years after the arrival of his parents and the remainder of his siblings, on the ship ELIZABETH at the port of Philadelphia in August of 1733. He is not on this passenger list. If this indeed his family, he would be born in Lancaster County, PA, where they resided until (estimated) 1744, where Simon Sr begins to appear in Frederick County, Virginia records.
WIFE: Mary Newland is the daughter of John Newland and Elizabeth Linder - his sister! Although often times first cousins are married, but within the large intermarrying families on record, an uncle and niece wedding would be a rare thing.